Treatment of polycythemia vera with hydroxyurea
نویسندگان
چکیده
منابع مشابه
How safe is hydroxyurea in the treatment of polycythemia vera?
How safe is hydroxyurea in the treatment of polycythemia vera? The global incidence of polycythemia vera (PV) is approximately 0.8-1.5 cases/100,000 popula-tion/year and increases linearly with age until 80, which suggests that several mutational somatic events are necessary. 1 Despite recent advances, the pathogenesis of PV remains far from clear (see a recent review in this journal). 2,3 Irre...
متن کاملHydroxyurea induced oscillations in twelve patients with polycythemia vera.
myeloproliferative neoplasms. Nat Genet. 2009;41(4):446-9. 6. Olcaydu D, Harutyunyan A, Jager R, Berg T, Gisslinger B, Pabinger I, et al. A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms. Nat Genet. 2009;41(4):4504. 7. Kilpivaara O, Mukherjee S, Schram AM, Wadleigh M, Mullally A, Ebert BL, et al. A germline JAK2 SNP is associated with predisposition to the developm...
متن کاملTreatment of polycythemia vera.
BACKGROUND AND OBJECTIVE Current guidelines for the management of patients with polycythemia vera (PV) derive from a few clinical trials and several uncontrolled clinical studies. The purpose of this paper is to critically review the available evidence in literature for selecting the best treatment in the single patient. METHODS The authors have been working in this field contributing origina...
متن کاملCutaneous effects after prolongaded use of hydroxyurea in Polycythemia Vera.
Hydroxyurea is an hydroxylated urea derivative used in many myeloproliferative disorders. Many, but unusual cutaneous disorders are related after its prolonged use. Their pathogenesis is not clear, but it is suggested that there is direct toxicity of the drug on the skin. We described a white, 75-year old man with diagnosis of Polycythemia Vera that in 11 years of treatment developed many cutan...
متن کاملHydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera.
Two prospectively studied patients with polycythemia vera (PV) whose platelet counts showed marked periodic fluctuation during treatment with hydroxyurea (HU) are reported. Cycle lengths in both were approximately 28 to 30 days. In one patient, the cyclic process was no longer evident when treatment with HU was withheld, and it reappeared on treatment rechallenge. Circulating thrombopoietin (TP...
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ژورنال
عنوان ژورنال: Cancer
سال: 1986
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19860215)57:4<718::aid-cncr2820570406>3.0.co;2-p